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Liberia - 9 Persons Die Mysteriously In Sinoe County

gnnliberia.com - by Cholo Brooks - April 25, 2017

Police in Sinoe County, southeastern Liberia, are investigation the mysterious death of nine persons after a repass of one late Edwin Dunbar, former Proprietor of One Family Entertainment Center who died few weeks ago in Greenville following a 2-night wake keeping.

According to our contact, those who died mysteriously include five females and four males, our contact said specimens from the nine deceased have been taken to Buchanan, Grand Bassa County for testing to establish the actual cause of death.

As a result of this terrible incident, officers of the Liberia National Police have been deployed in the streets of Greenville using mega phones and requesting those who ate the repass to report themselves.

Our contact said the strange and disturbing situation has created panic among citizens of the County, with others leaving for their towns and villages for fear of the unexpected.

County Health Officer John Logan when asked by our contact to speak on this prevailing situation, as to what is responsible for the mysterious deaths declined to comment on the issue.

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Huge Genome Study Dissects Ebola Outbreak's Spread

NSAID / Flickr

CLICK HERE - Nature - Virus genomes reveal factors that spread and sustained the Ebola epidemic

cidrap.umn.edu - Lisa Schnirring - April 14, 2017

The largest genome sample ever analyzed for a human epidemic reveals that the West Africa epidemic unfolded with small, overlapping outbreaks as the virus spread over short distances and that urban settings amplified the spread.

Meanwhile, another study harnessed different advanced scientific tools in the blood of a single sick patient to detail gene-level response during infection.

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CLICK HERE - Science Translational Medicine - Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease

 

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International Research Effort Reveals Major Insights Into Spread of West African Ebola Epidemic

news-medical.net - April 12, 2017

CLICK HERE - RESEARCH - Nature - Virus genomes reveal factors that spread and sustained the Ebola epidemic

An international effort to analyze the entire database of Ebola virus genomes from the 2013-2016 West African epidemic reveals insights into factors that sped or slowed the rampage and calls for using real-time sequencing and data-sharing to contain future viral disease outbreaks.

Published today in the journal Nature, the analysis found that the epidemic unfolded in small, overlapping outbreaks with surprisingly few infected travelers sparking new outbreaks elsewhere, each case representing a missed opportunity to break the transmission chain and end the epidemic sooner.

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ALSO SEE RELATED ARTICLE HERE - A big-picture look at the world’s worst Ebola epidemic

 

 

 

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Blocking TLR4 Pathway May Help Control Ebola Infection

Boston University scientists curbed the host response to Ebola infection by inhibiting TLR4 in macrophages. (CDC Global CC BY 2.0)

CLICK HERE - Virology - Ebolaviruses associated with differential pathogenicity induce distinct host responses in human macrophages

fiercebiotech.com - by Amirah Al Idrus - March 23, 2017

The Ebola virus causes a disease that is often fatal, in part by infecting white blood cells called macrophages and disrupting their immune response. Boston University scientists found that using drugs that block the protein TLR4 can suppress this response and potentially control infection.

Macrophages are responsible for detecting and destroying pathogens, but the Ebola virus activates them through the Toll-like receptor 4 (TLR4) pathway, causing an inappropriate immune response. The Ebola-infected macrophages end up producing excess cytokines and chemokines—proteins that promote inflammation and worsen the disease.

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Tiny Genetic Change Lets Bird Flu Leap to Humans

           

At least six provinces have reported human cases of H7N9 influenza this year, according to Chinese state media - Getty Images

CLICK HERE - STUDY - Nature Communications - An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells

bbc.com - March 21, 2017

A change in just a single genetic "letter" of the flu virus allows bird flu to pass to humans, according to scientists.

Monitoring birds for viruses that carry the change could provide early warning of risk to people, they say . . .

 . . . The change in a single nucleotide (a building block of RNA) allows the H7N9 virus to infect human cells as well as birds, say Prof Honglin Chen and colleagues.

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CDC Reports Pneumonia, Influenza Mortality Rate Hits Epidemic Threshold

CLICK HERE - CDC - FLUVIEW - Weekly U.S. Influenza Surveillance Report

CLICK HERE - CDC - Weekly US Map: Influenza Summary Update

CLICK HERE - CDC - Situation Update: Summary of Weekly FluView Report

CLICK HERE - CDC - Past Weekly Surveillance Reports

healio.com - February 10, 2017

The mortality rate for pneumonia and influenza in the United States was slightly above the epidemic threshold during the week ending Jan. 7, according to CDC’s FluView.

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The Mission to Stop Ebola: Lessons for UN Crisis Response

CLICK HERE - International Peace Institute - The Mission to Stop Ebola: Lessons for UN Crisis Response (28 page .PDF report)

reliefweb.int - February 15, 2017
ADAM LUPEL AND MICHAEL SNYDER

Executive Summary

The Ebola epidemic of 2014–2016 was a fastmoving, multidimensional emergency that pre - sented unprecedented challenges for the multi - lateral system. In response to the outbreak, which was spreading exponentially in Guinea, Liberia, and Sierra Leone, Secretary-General Ban Ki-moon established the UN’s first-ever emergency health mission, the UN Mission for Ebola Emergency Response (UNMEER). UNMEER was mandated by the UN General Assembly in September 2014 to scale up and coordinate the activities of the UN presence on the ground working to stop the outbreak, which eventually claimed over 11,000 lives.

This report asks: Was UNMEER needed? Was it properly structured? Did it deliver? And what broader lessons can be learned from the experience of UNMEER for UN crisis response?

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Ebola 'Super-Spreaders' Cause Most Cases

           

Getty Images

CLICK HERE - PNAS - Spatial and temporal dynamics of superspreading events in the 2014–2015 West Africa Ebola epidemic

bbc.com - by James Gallagher - February 14, 2017

The majority of cases in the world's largest outbreak of Ebola were caused by a tiny handful of patients, research suggests.

The analysis, published in Proceedings of the National Academy of Sciences, shows nearly two thirds of cases (61%) were caused by 3% of infected people.

The young and old were more likely to have been "super-spreaders".

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ALSO SEE RELATED ARTICLES WITHIN THE LINKS BELOW . . .

CLICK HERE - Disease “superspreaders” were driving cause of 2014 Ebola epidemic

CLICK HERE - Superspreaders Drove Ebola Epidemic, Study Finds

 

 

 

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First Ebola-Related Death from Breast Milk Transmission Reported in Guinea

Sissoko D, et al. Clin Infect Dis. 2016;doi:10.1093/cid/ciw79.

CLICK HERE - STUDY -  Ebola virus persistence in breast milk after no reported illness: a likely source of virus transmission from mother to child

healio.com - January 10, 2017

Genomic analysis confirmed that the 2015 death of a 9-month-old Guinean infant from Ebola virus was the result of transmission through the breast milk of her asymptomatic mother, according to a recent case study.

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