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First Ebola-Related Death from Breast Milk Transmission Reported in Guinea

Sissoko D, et al. Clin Infect Dis. 2016;doi:10.1093/cid/ciw79.

CLICK HERE - STUDY -  Ebola virus persistence in breast milk after no reported illness: a likely source of virus transmission from mother to child

healio.com - January 10, 2017

Genomic analysis confirmed that the 2015 death of a 9-month-old Guinean infant from Ebola virus was the result of transmission through the breast milk of her asymptomatic mother, according to a recent case study.

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Ebola RNA Found Hiding in Healthcare Worker’s Lungs

           

WIKIMEDIA, HELLERHOFF

CLICK HERE - STUDY - Detection of Viral RNA in Tissues following Plasma Clearance from an Ebola Virus Infected Patient

A case study reports evidence of viral replication lingering in the respiratory tract of an infected person, even after their blood was Ebola free.

the-scientist.com - by Bob Grant - January 5, 2017

Ebola virus may linger and continue to replicate in the lungs of patients recovering from infection, even after viral RNA is no longer detectable in their bloodstreams, according to a case study published today (January 5) in PLOS Pathogens. . . .

 . . . Ippolito and his colleagues monitored the Ebola-infected patient, who was moved from West Africa to a hospital in Italy in 2015, over the course of their infection. They found viral RNA and other markers of viral replication in the patient’s lungs five days after such markers were no longer detectable in the blood.

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Final Trial Results Confirm Ebola Vaccine Provides High Protection Against Disease

                                               

who.int

23 DECEMBER 2016 | GENEVA - An experimental Ebola vaccine was highly protective against the deadly virus in a major trial in Guinea, according to results published today in The Lancet. The vaccine is the first to prevent infection from one of the most lethal known pathogens, and the findings add weight to early trial results published last year.

The vaccine, called rVSV-ZEBOV, was studied in a trial involving 11 841 people in Guinea during 2015. Among the 5837 people who received the vaccine, no Ebola cases were recorded 10 days or more after vaccination. In comparison, there were 23 cases 10 days or more after vaccination among those who did not receive the vaccine.

The trial was led by WHO, together with Guinea’s Ministry of Health and other international partners.

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CLICK HERE - The Lancet - Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)

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Ebola Cluster Traced to Sexual Transmission 15 Months After Man's Illness

cidrap.umn.edu - September 2, 2016

A cluster of Ebola cases in Guinea earlier this year has been traced to sexual transmission from a man who had recovered from the disease close to 15 months earlier, marking the longest known period of sexual transmissibility after recovery from the disease.

"Evidence for sexual transmission of the persisting EBOV in February 2016, about 470 days after onset of symptoms in the survivor, is compelling," says the report by an international team of researchers, published yesterday in Clinical Infectious Diseases.

The cluster involved 3 probable and 7 confirmed cases in Guinea, with 8 deaths, in February, March, and April of this year, the report says.

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CLICK HERE - CID - Resurgence of Ebola virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days

 

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Ebola Virus Persists in Semen Far Longer Than Thought, Study Finds

statnews.com - by Helen Branswell - August 30, 2016

CLICK HERE - The Lancet Global Health - Prevention of sexual transmission of Ebola in Liberia through a national semen testing and counselling programme for survivors: an analysis of Ebola virus RNA results and behavioural data

The Ebola virus can hide itself in the testicles of men who’ve survived the disease for far longer than had been previously thought, a new study suggests.

In fact, the research reports on a man who was still emitting fragments of Ebola viruses in his semen 565 days after he became ill — or 18 months. . . .

. . . suggesting it may be due to age-related changes in the immune system.

. . . The work, published Tuesday in the journal Lancet Global Health, was done by scientists from the Liberian Ministry of Health, the Centers for Disease Control and Prevention, and the World Health Organization. . . .

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How Likely Are You To Deal With A Zika Outbreak? Check This Map

huffingtonpost.com - August 15th 2016 - Anna Almendrala

Now that Zika virus is spreading locally in Florida, U.S. residents, and especially pregnant women, are growing alarmed at the risk that they may face in their own communities. 

A new map estimating the risk of local Zika spread around the globe shows a relatively small likelihood that most of North America and Northern Asia will be affected. By contrast, all the variables are in place for local spread in most of Africa, South and Southeast Asia. 

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CDC - MMWR - Incident Management Systems and Building Emergency Management Capacity During the 2014–2016 Ebola Epidemic - Liberia, Sierra Leone, and Guinea

cdc.gov - July 8, 2016

Summary

Establishing a functional incident management system (IMS) is important in the management of public health emergencies. In response to the 2014–2016 Ebola virus disease (Ebola) epidemic in West Africa, CDC established the Emergency Management Development Team (EMDT) to coordinate technical assistance for developing emergency management capacity in Guinea, Liberia, and Sierra Leone. EMDT staff, deployed staff, and partners supported each country to develop response goals and objectives, identify gaps in response capabilities, and determine strategies for coordinating response activities. To monitor key programmatic milestones and assess changes in emergency management and response capacities over time, EMDT implemented three data collection methods in country: coordination calls, weekly written situation reports, and an emergency management dashboard tool. On the basis of the information collected, EMDT observed improvements in emergency management capacity over time in all three countries. The collaborations in each country yielded IMS structures that streamlined response and laid the foundation for long-term emergency management programs.

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Report of the Independent Panel on the U.S. Department of Health and Human Services (HHS) Ebola Response

                    

disasterlit.nlm.nih.gov - June 30, 2016

This 57-page report summarizes a request to capture critical lessons from the Ebola epidemic of 2014-2016 and review the Department of Health and Human Services (HHS)'s international and domestic responses. It summarizes an Independent Panel's assessment of HHS's challenges, and, where appropriate, challenges facing the broader U.S. government. It describes notable opportunities for improvement in leadership and organization, communication, management, and logistics, as well as in development and use of vaccines and treatments. It also presents recommendations for addressing future urgent public health threats.

CLICK HERE - ADDITIONAL INFORMATION AND ACCESS TO THE REPORT - Report of the Independent Panel on the U.S. Department of Health and Human Services (HHS) Ebola Response

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CLICK HERE - ADDITIONAL INFORMATION AND ACCESS TO THE REPORT - Report of the Review Committee on the Role of the International Health Regulations (2005) in the Ebola Outbreak and Response

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Ibuprofen 'Disables' Ebola Virus

SPL

CLICK HERE - RESEARCH - Nature - Toremifene interacts with and destabilizes the Ebola virus glycoprotein

bbc.com - by James Gallagher - June 30, 2016

The painkiller ibuprofen and the cancer drug toremifene can disable the Ebola virus, say researchers.

Scientists used the UK's national synchrotron facility - Diamond Light Source - to analyse the virus in incredible detail.

They revealed the two drugs could bind to the crucial part of Ebola that the virus needs to infect cells.

However, the team warns this is just a starting point and more effective drugs need to be researched.

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ADDITIONAL REFERENCES ARE PROVIDED BELOW:

Toremifene interacts with and destabilizes the Ebola virus glycoprotein
http://www.nature.com/nature/archive/subject.html?code=326

Toremifene interacts with and destabilizes the Ebola virus glycoprotein
http://www.nature.com/subjects/ebola-virus

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