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London Group Plans to Start First Clinical Tests of Ebola Drugs in West Africa

Washington Post

by Abby Ohlheiser September 23 at 11:45 AM

London based scientists, working with international aid groups, are planning to start the first clinical trials in West Africa for drugs to treat Eboa. The trials could begin in a matter of months.

Wellcome Trust's $5 million initiative will include drugs from Mapp Biopharmaceutical, Sarepta and Tekmira, according to Reuters. Mapp makes zMapp, the experimental cocktail administered to two Americans who contracted the disease in Liberia. Tekmira recently gained the approval of the U.S. Food and Drug Administration to use its TKM-Ebola treatment on confirmed or suspected cases of the disease.

Both drugs are still in the experimental phase; researchers have not yet determined the safety or effectiveness of the treatments.

Text of full story:

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EBOLA MAY BECOME ENDEMIC TO WEST AFRICA WITH 71 PER CENT INFECTION RATE--WHO STUDY

LOS ANGLES TIMES     September 22, 10:25 PM

by Monte Morin

In a grim assessment of the Ebola epidemic, researchers say the deadly virus threatens to become endemic to West Africa instead of eventually disappearing from humans.

"The current epidemiologic outlook is bleak," wrote a panel of more than 60 World Health Organization experts in a study published Tuesday by the New England Journal of Medicine.

"We must therefore face the possibility that Ebola virus disease will become endemic among the human population of West Africa, a prospect that has never previously been contemplated."

In the absence of new control measures, the authors estimated that the total case load would exceed 20,000 by Nov 2.

Link to full story

http://www.latimes.com/science/sciencenow/la-sci-sn-ebola-may-be-endemic-in-people-20140922-story.html

Link to New England Journal of Medicine study

http://www.nejm.org/doi/full/10.1056/NEJMoa1411100?query=featured_ebola

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WHO PLAN WOULD MOVE INFECTED PERSONS FROM HOMES TO COMMUNITY CENTERS

Washington Post  September 23, 014
by Lenny Bernstein and Lena H. Sun

MONROVIA, LIBERIA  -The Liberian government, the World Health Organization and their nonprofit partners here are launching an ambitious but controversial program to move infected people out of their homes and into ad hoc centers that will provide rudimentary care, officials said Monday.

The community centers would supplement hospitals.

However Doctors Without Borders Director of operations says "this is not going to work," saying the infected countries do not have the needed infrastructure.

http://www.washingtonpost.com/national/health-science/new-effort-to-fight-ebola-in-liberia-would-move-infected-patients-out-of-their-homes/2014/09/22/f869dc08-4281-11e4-b47c-f5889e061e5f_story.html?hpid=z5

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WHO SAYS EBOLA "CONTAINED" IN NIGERIA AND SENEGAL

REUTERS

An outbreak of Ebola in West Africa has been largely contained in Senegal and Nigeria, the World Health Organization said on Monday, but the disease is still spreading elsewhere and has now killed over 2,811 people in the region.

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BBC Update: Sierra Leone Lockdown Called a Success

BBC         22 September 2014 Last updated at 14:11 ET

A three-day curfew aimed at containing the Ebola outbreak in Sierra Leone has been declared a success by authorities.

They say more than a million households were surveyed and 130 new cases discovered.

Sierra Leone is one of the countries worst affected by the outbreak, with nearly 600 of the almost 2,800 total deaths recorded so far.

Some health groups have criticised the lockdown, saying it would destroy trust between patients and doctors.

Nearly all of the deaths in the world's worst Ebola outbreak have been recorded in Guinea, Liberia and Sierra Leone.

The World Health Organization (WHO) says the situations in Senegal and Nigeria have now been "pretty much contained".

According to the UN agency, the number of overall deaths from Ebola has risen to 2,793 and the disease remains "a public health emergency of international concern".

The deadly virus is transmitted through sweat, blood and saliva, and there is no proven cure.

A Spanish priest who contracted the virus whilst working in Sierra Leone was flown back to Spain for treatment

In other developments:

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Liberian Minister Says Ebola Threatens Collapse of Three Nations

The Independent   Sept. 21

by Charlie Cooper

West Africa’s Ebola epidemic threatens the “collapse” of three entire states, a Liberian minister has warned. Speaking exclusively to The Independent on Sunday, information minister Lewis Brown said that the international media had failed to “appreciate” the scale of an epidemic that has gone beyond a health crisis to threaten “every aspect of [Liberia’s] national existence”.

“People need to understand, what we are dealing with has the potential to collapse our three countries,” he said, referring to Liberia and neighbouring Guinea and Sierra Leone. “Liberia was in its 11th year of peace. We experienced, because of our war, a 90 per cent collapse in the productive sector of our economy, we were rebuilding and our health infrastructure was not what it should have been. We were just bringing back hope and life when we were struck by Ebola. It is having terrible consequences for every aspect of our national existence.”

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THE FEAR THAT KILLED 8 EBOLA WORKERS

 

 

The Daily Beast September 20, 2014
By Abby Haglage     

They were sent in to help educate villagers about how to ward off the lethal virus. Then fear took over and the machetes came out.

At the time of Wednesday’s announc

ement out of Guinea that seven of nine missing Ebola workers had been found dead, we knew little. Men with knives had abducted members of a group sent there to spread awareness about the disease. Two relief workers were missing; the rest, dead. Six suspects were in custody.

By Friday morning, we knew more. These details, the stuff of horror films. A local government group of relief workers—a mix of doctors, religious leaders, and journalists—had arrived Monday to educate the remote southeastern village of Womey about Ebola. Just 24 hours after their arrival, violence broke out, allegedly sparked by the false belief that a disinfectant being sprayed was actually the disease itself. An angry mob brandishing machetes, stones, and knives lashed out.

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A New Health Crisis in Liberia

Washington Post

By Lenny Bernstein September 21, Front Page

MONROVIA, Liberia — While the terrifying spread of Ebola has captured the world’s attention, it also has produced a lesser-known crisis: the near-collapse of the already fragile health-care system here, a development that may be as dangerous — for now — as the virus for the average Liberian.

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Sierra Leone Medical Team attacked

 

 

FREETOWN, Sun Sep 21, 2014 Reuters

 

 
 
 

1 of 2. Medical staff working with Medecins sans Frontieres (MSF) prepare to bring food to patients kept in an isolation area at the MSF Ebola treatment centre in Kailahun July 20, 2014.

Credit: Reuters/Tommy Trenchard

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