You are here


Forty Years Later, Ebola Survivors are Still Making Antibodies to the Lethal Virus


Lab technician and Ebola survivor Sukato Mandzomba (front) worked with Peter Piot (back) in 1976 and again in 2016.  Heidi Larson

CLICK HERE - STUDY - Ebola Virus Neutralizing Antibodies Detectable in Survivors of theYambuku, Zaire Outbreak 40 Years after Infection - by Jon Cohen - December 14, 2017

Forty years after the first documented Ebola outbreak, some of the survivors still have antibodies against the virus, a new study reveals. The find bolsters the widely held assumption that Ebola survivors remain immune to the virus for life. The work may also help guide development of new medicines and clarify the long-term health consequences of an Ebola infection.




General Topic Tags: 
Problem, Solution, SitRep, or ?: 

Huge Genome Study Dissects Ebola Outbreak's Spread

NSAID / Flickr

CLICK HERE - Nature - Virus genomes reveal factors that spread and sustained the Ebola epidemic - Lisa Schnirring - April 14, 2017

The largest genome sample ever analyzed for a human epidemic reveals that the West Africa epidemic unfolded with small, overlapping outbreaks as the virus spread over short distances and that urban settings amplified the spread.

Meanwhile, another study harnessed different advanced scientific tools in the blood of a single sick patient to detail gene-level response during infection.


CLICK HERE - Science Translational Medicine - Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease


Country / Region Tags: 
General Topic Tags: 
Problem, Solution, SitRep, or ?: 

International Research Effort Reveals Major Insights Into Spread of West African Ebola Epidemic - April 12, 2017

CLICK HERE - RESEARCH - Nature - Virus genomes reveal factors that spread and sustained the Ebola epidemic

An international effort to analyze the entire database of Ebola virus genomes from the 2013-2016 West African epidemic reveals insights into factors that sped or slowed the rampage and calls for using real-time sequencing and data-sharing to contain future viral disease outbreaks.

Published today in the journal Nature, the analysis found that the epidemic unfolded in small, overlapping outbreaks with surprisingly few infected travelers sparking new outbreaks elsewhere, each case representing a missed opportunity to break the transmission chain and end the epidemic sooner.


ALSO SEE RELATED ARTICLE HERE - A big-picture look at the world’s worst Ebola epidemic




General Topic Tags: 
Problem, Solution, SitRep, or ?: 

Blocking TLR4 Pathway May Help Control Ebola Infection

Boston University scientists curbed the host response to Ebola infection by inhibiting TLR4 in macrophages. (CDC Global CC BY 2.0)

CLICK HERE - Virology - Ebolaviruses associated with differential pathogenicity induce distinct host responses in human macrophages - by Amirah Al Idrus - March 23, 2017

The Ebola virus causes a disease that is often fatal, in part by infecting white blood cells called macrophages and disrupting their immune response. Boston University scientists found that using drugs that block the protein TLR4 can suppress this response and potentially control infection.

Macrophages are responsible for detecting and destroying pathogens, but the Ebola virus activates them through the Toll-like receptor 4 (TLR4) pathway, causing an inappropriate immune response. The Ebola-infected macrophages end up producing excess cytokines and chemokines—proteins that promote inflammation and worsen the disease.


General Topic Tags: 
Problem, Solution, SitRep, or ?: 

The Mission to Stop Ebola: Lessons for UN Crisis Response

CLICK HERE - International Peace Institute - The Mission to Stop Ebola: Lessons for UN Crisis Response (28 page .PDF report) - February 15, 2017

Executive Summary

The Ebola epidemic of 2014–2016 was a fastmoving, multidimensional emergency that pre - sented unprecedented challenges for the multi - lateral system. In response to the outbreak, which was spreading exponentially in Guinea, Liberia, and Sierra Leone, Secretary-General Ban Ki-moon established the UN’s first-ever emergency health mission, the UN Mission for Ebola Emergency Response (UNMEER). UNMEER was mandated by the UN General Assembly in September 2014 to scale up and coordinate the activities of the UN presence on the ground working to stop the outbreak, which eventually claimed over 11,000 lives.

This report asks: Was UNMEER needed? Was it properly structured? Did it deliver? And what broader lessons can be learned from the experience of UNMEER for UN crisis response?

Problem, Solution, SitRep, or ?: 

Ebola 'Super-Spreaders' Cause Most Cases


Getty Images

CLICK HERE - PNAS - Spatial and temporal dynamics of superspreading events in the 2014–2015 West Africa Ebola epidemic - by James Gallagher - February 14, 2017

The majority of cases in the world's largest outbreak of Ebola were caused by a tiny handful of patients, research suggests.

The analysis, published in Proceedings of the National Academy of Sciences, shows nearly two thirds of cases (61%) were caused by 3% of infected people.

The young and old were more likely to have been "super-spreaders".



CLICK HERE - Disease “superspreaders” were driving cause of 2014 Ebola epidemic

CLICK HERE - Superspreaders Drove Ebola Epidemic, Study Finds




General Topic Tags: 
Problem, Solution, SitRep, or ?: 

7 Forgotten World Crises That Urgently Need Your Support

The global need for humanitarian aid has reached a level not seen since World War II. More than 128 million people in 33 countries are now affected by crises, including conflict and natural disaster.

Problem, Solution, SitRep, or ?: 

First Ebola-Related Death from Breast Milk Transmission Reported in Guinea

Sissoko D, et al. Clin Infect Dis. 2016;doi:10.1093/cid/ciw79.

CLICK HERE - STUDY -  Ebola virus persistence in breast milk after no reported illness: a likely source of virus transmission from mother to child - January 10, 2017

Genomic analysis confirmed that the 2015 death of a 9-month-old Guinean infant from Ebola virus was the result of transmission through the breast milk of her asymptomatic mother, according to a recent case study.

General Topic Tags: 
Problem, Solution, SitRep, or ?: 

Ebola RNA Found Hiding in Healthcare Worker’s Lungs



CLICK HERE - STUDY - Detection of Viral RNA in Tissues following Plasma Clearance from an Ebola Virus Infected Patient

A case study reports evidence of viral replication lingering in the respiratory tract of an infected person, even after their blood was Ebola free. - by Bob Grant - January 5, 2017

Ebola virus may linger and continue to replicate in the lungs of patients recovering from infection, even after viral RNA is no longer detectable in their bloodstreams, according to a case study published today (January 5) in PLOS Pathogens. . . .

 . . . Ippolito and his colleagues monitored the Ebola-infected patient, who was moved from West Africa to a hospital in Italy in 2015, over the course of their infection. They found viral RNA and other markers of viral replication in the patient’s lungs five days after such markers were no longer detectable in the blood.


General Topic Tags: 
Problem, Solution, SitRep, or ?: 


Subscribe to Guinea
howdy folks