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Ebola RNA Found Hiding in Healthcare Worker’s Lungs

           

WIKIMEDIA, HELLERHOFF

CLICK HERE - STUDY - Detection of Viral RNA in Tissues following Plasma Clearance from an Ebola Virus Infected Patient

A case study reports evidence of viral replication lingering in the respiratory tract of an infected person, even after their blood was Ebola free.

the-scientist.com - by Bob Grant - January 5, 2017

Ebola virus may linger and continue to replicate in the lungs of patients recovering from infection, even after viral RNA is no longer detectable in their bloodstreams, according to a case study published today (January 5) in PLOS Pathogens. . . .

 . . . Ippolito and his colleagues monitored the Ebola-infected patient, who was moved from West Africa to a hospital in Italy in 2015, over the course of their infection. They found viral RNA and other markers of viral replication in the patient’s lungs five days after such markers were no longer detectable in the blood.

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Final Trial Results Confirm Ebola Vaccine Provides High Protection Against Disease

                                               

who.int

23 DECEMBER 2016 | GENEVA - An experimental Ebola vaccine was highly protective against the deadly virus in a major trial in Guinea, according to results published today in The Lancet. The vaccine is the first to prevent infection from one of the most lethal known pathogens, and the findings add weight to early trial results published last year.

The vaccine, called rVSV-ZEBOV, was studied in a trial involving 11 841 people in Guinea during 2015. Among the 5837 people who received the vaccine, no Ebola cases were recorded 10 days or more after vaccination. In comparison, there were 23 cases 10 days or more after vaccination among those who did not receive the vaccine.

The trial was led by WHO, together with Guinea’s Ministry of Health and other international partners.

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CLICK HERE - The Lancet - Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)

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How Ebola Adapted to Us

Ebola virus particles (blue) budding from an infected cell. National Institute of Allergy and Infectious Diseases, National Institutes of Health

Image: Ebola virus particles (blue) budding from an infected cell. National Institute of Allergy and Infectious Diseases, National Institutes of Health

theatlantic.com - November 3rd 2016 - Ed Yong

In December 2013, in a small village in Guinea, the Ebola virus left its traditional host—probably a bat—and infected a young boy. That leap triggered what became the largest Ebola outbreak in history. At first, the virus stayed within Guinea’s borders and, as in every previous epidemic, affected just a few hundred people.

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Post-Ebola, West Africans Flock Back to Bushmeat, With Risk

submitted by Jeff Williams

            

FILE-In this file photo taken on Wednesday, Oct. 22, 2014, Yaa Kyarewaa, await clients as she stands next to her makeshift bush meat shop at one of the largest local markets in Accra, Ghana. As the deadly outbreak of Ebola has subsided, people in several West African countries are flocking to eat bush meat again after restrictions were lifted on the consumption of wild animals like hedgehogs and cane rats. But some health experts call it a risky move. (AP Photo/Christian Thompson, File) 

Associated Press - by HILAIRE ZON and CARLEY PETESCH - September 21, 2016

ABIDJAN, Ivory Coast (AP) — As the deadly outbreak of Ebola has subsided, people in several West African countries are flocking to eat bushmeat again after restrictions were lifted on the consumption of wild animals like hedgehogs and cane rats. But some health experts call it a risky move.

Ivory Coast, which neighbors two of the three countries where Ebola killed more than 11,300 people since December 2013, lifted its ban on wild animal meat this month.

The meat of squirrel, deer, fruit bats and rats has long been a key source of protein for many in the region, but it is also a potential source of the Ebola virus.

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Ebola Cluster Traced to Sexual Transmission 15 Months After Man's Illness

cidrap.umn.edu - September 2, 2016

A cluster of Ebola cases in Guinea earlier this year has been traced to sexual transmission from a man who had recovered from the disease close to 15 months earlier, marking the longest known period of sexual transmissibility after recovery from the disease.

"Evidence for sexual transmission of the persisting EBOV in February 2016, about 470 days after onset of symptoms in the survivor, is compelling," says the report by an international team of researchers, published yesterday in Clinical Infectious Diseases.

The cluster involved 3 probable and 7 confirmed cases in Guinea, with 8 deaths, in February, March, and April of this year, the report says.

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CLICK HERE - CID - Resurgence of Ebola virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days

 

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Ebola Virus Persists in Semen Far Longer Than Thought, Study Finds

statnews.com - by Helen Branswell - August 30, 2016

CLICK HERE - The Lancet Global Health - Prevention of sexual transmission of Ebola in Liberia through a national semen testing and counselling programme for survivors: an analysis of Ebola virus RNA results and behavioural data

The Ebola virus can hide itself in the testicles of men who’ve survived the disease for far longer than had been previously thought, a new study suggests.

In fact, the research reports on a man who was still emitting fragments of Ebola viruses in his semen 565 days after he became ill — or 18 months. . . .

. . . suggesting it may be due to age-related changes in the immune system.

. . . The work, published Tuesday in the journal Lancet Global Health, was done by scientists from the Liberian Ministry of Health, the Centers for Disease Control and Prevention, and the World Health Organization. . . .

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CDC - MMWR - Incident Management Systems and Building Emergency Management Capacity During the 2014–2016 Ebola Epidemic - Liberia, Sierra Leone, and Guinea

cdc.gov - July 8, 2016

Summary

Establishing a functional incident management system (IMS) is important in the management of public health emergencies. In response to the 2014–2016 Ebola virus disease (Ebola) epidemic in West Africa, CDC established the Emergency Management Development Team (EMDT) to coordinate technical assistance for developing emergency management capacity in Guinea, Liberia, and Sierra Leone. EMDT staff, deployed staff, and partners supported each country to develop response goals and objectives, identify gaps in response capabilities, and determine strategies for coordinating response activities. To monitor key programmatic milestones and assess changes in emergency management and response capacities over time, EMDT implemented three data collection methods in country: coordination calls, weekly written situation reports, and an emergency management dashboard tool. On the basis of the information collected, EMDT observed improvements in emergency management capacity over time in all three countries. The collaborations in each country yielded IMS structures that streamlined response and laid the foundation for long-term emergency management programs.

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World Bank Contributes to Improved Disease Surveillance and Health Systems in West Africa following Ebola Epidemic

                                                

worldbank.org

WASHINGTON, June 29, 2016—In Guinea, Sierra Leone and Senegal, more than 33.3 million people will benefit from stronger health systems and more effective disease surveillance systems through US$110 million in International Development Association (IDA) financing, approved yesterday by the World Bank Group’s Board of Executive Directors. This is the first in a series of investments planned under the Regional Disease Surveillance Systems Enhancement Program (REDISSE), which aims to address systemic weaknesses within the human and animal health sectors that hinder effective disease surveillance and response. The REDISSE program was developed with financial support from the Bill & Melinda Gates Foundation and technical support from the World Health Organization and the U.S. Centers for Disease Control and Prevention.

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Report of the Independent Panel on the U.S. Department of Health and Human Services (HHS) Ebola Response

                    

disasterlit.nlm.nih.gov - June 30, 2016

This 57-page report summarizes a request to capture critical lessons from the Ebola epidemic of 2014-2016 and review the Department of Health and Human Services (HHS)'s international and domestic responses. It summarizes an Independent Panel's assessment of HHS's challenges, and, where appropriate, challenges facing the broader U.S. government. It describes notable opportunities for improvement in leadership and organization, communication, management, and logistics, as well as in development and use of vaccines and treatments. It also presents recommendations for addressing future urgent public health threats.

CLICK HERE - ADDITIONAL INFORMATION AND ACCESS TO THE REPORT - Report of the Independent Panel on the U.S. Department of Health and Human Services (HHS) Ebola Response

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CLICK HERE - ADDITIONAL INFORMATION AND ACCESS TO THE REPORT - Report of the Review Committee on the Role of the International Health Regulations (2005) in the Ebola Outbreak and Response

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Ibuprofen 'Disables' Ebola Virus

SPL

CLICK HERE - RESEARCH - Nature - Toremifene interacts with and destabilizes the Ebola virus glycoprotein

bbc.com - by James Gallagher - June 30, 2016

The painkiller ibuprofen and the cancer drug toremifene can disable the Ebola virus, say researchers.

Scientists used the UK's national synchrotron facility - Diamond Light Source - to analyse the virus in incredible detail.

They revealed the two drugs could bind to the crucial part of Ebola that the virus needs to infect cells.

However, the team warns this is just a starting point and more effective drugs need to be researched.

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ADDITIONAL REFERENCES ARE PROVIDED BELOW:

Toremifene interacts with and destabilizes the Ebola virus glycoprotein
http://www.nature.com/nature/archive/subject.html?code=326

Toremifene interacts with and destabilizes the Ebola virus glycoprotein
http://www.nature.com/subjects/ebola-virus

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