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Guinea Resilience System

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The Guinea Resilience System working group is focused on the development of Resilience Systems in Guinea.

The mission of the Guinea Resilience System working group is to develop Resilience Systems and their nested subsystems in Guinea.

Members

Abdoulaye Drame Aboubacar Conte Anthony Boubacar Kaba Carrielaj Chisina Kapungu
Elhadj Drame Hadiatou Balde Ismael Dioubate John Wysham Kathy Gilbeaux Lancine Konate
Mamadou Diallo Mamadou Moustap... Mamadou Sylla mdmcdonald MDMcDonald_me_com mike kraft
Norea Souleymane Drame

Email address for group

guinea-resilience-system@m.resiliencesystem.org

Drowning Megacities

             

interactive.aljazeera.com - 2015

The world is getting warmer, the rain is growing heavier and the oceans are rising. At the same time, the world’s rural inhabitants are migrating to its cities on a massive scale.

Sub-Saharan Africa is the part of the world most affected by the dual pressure of climate change and the rapid, uncontrolled transformation of its cities into megacities.

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WHO Publishes List of Top Emerging Diseases Likely to Cause Major Epidemics

              

WHO Strategic Health Operations Centre (SHOC) Room - WHO /Christopher Black

who.int

A panel of scientists and public health experts convened by WHO met in Geneva this week to prioritise the top five to ten emerging pathogens likely to cause severe outbreaks in the near future, and for which few or no medical countermeasures exist. These diseases will provide the basis for work on the WHO Blueprint for R&D preparedness to help control potential future outbreaks.

The initial list of disease priorities needing urgent R&D attention comprises: Crimean Congo haemorrhagic fever, Ebola virus disease and Marburg, Lassa fever, MERS and SARS coronavirus diseases, Nipah and Rift Valley fever. The list will be reviewed annually or when new diseases emerge.

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ALSO SEE RELATED ARTICLE HERE - The most dangerous pathogens, according to WHO

 

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Some communities are destroyed by tragedy and disaster. Others spring back. Here’s what makes the difference.

             

Cindy Quinonez, center, whose cousin Aurora Godoy was killed in last week’s shooting rampage, attends a makeshift memorial Tuesday in San Bernardino, Calif. (AP Photo/Jae C. Hong)

washingtonpost.com - by Daniel Aldrich - December 9, 2015

How do people survive and move on from tragedies like last week’s terrorist attacks at home and abroad? When does a tragedy — whether human-made or natural disaster or a combination of the two — destroy a community, and when do they recover and thrive? . . .

. . . The answer is in an often misunderstood concept called “resilience.”

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We’ve Learnt Many Lessons from This Outbreak and From the Response – Dr. David Nabarro, Special Envoy on Ebola

          

Dr. David Nabarro, Special Envoy on Ebola, at a press conference in New York in November 2015. UN Photo/Loey Felipe

un.org

10 December 2015 – In August 2014, amid a rapidly growing outbreak of Ebola, Dr. David Nabarro was tasked with providing strategic guidance for an enhanced international response, and galvanizing essential support for affected communities and countries. As the Secretary-General’s Special Envoy on Ebola, Dr. Nabarro played a key role in responding to the outbreak, which mainly affected Guinea, Liberia and Sierra Leone, and claimed more than 11,300 lives to date.

While the Ebola outbreak in West Africa has declined significantly in recent months, it is not completely over, making it all the more vital for everyone involved in the response to remain vigilant and focused on stopping the outbreak, staying at zero cases and preventing re-emergence. The Office of the Special Envoy will end its mandate on 31 December 2015, but the UN system will continue to remain fully engaged with the affected countries. 

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Liberia’s Ebola Outbreak Largely Traced to One Source

            

BRANCHING OUT  In Liberia, a single lineage of Ebola virus (middle dot) split into subgroups as it passed from person to person and mutated. Each dot is a slightly different version of the virus within the subgroups. Dot size indicates how many people carried that version. Researchers tracked the virus as it spread from Liberia (blue) into Guinea (red) and Mali (yellow).  J.T. Ladner et al/Cell Host & Microbe 2015

CLICK HERE - STUDY - Evolution and Spread of Ebola Virus in Liberia, 2014–2015

Genetic analysis of third hard-hit country fills in gaps in virus’ spread and evolution

sciencenews.org - by Tina Hesman Saey - December 9, 2015

A single introduction of the Ebola virus led to most cases of the deadly disease in Liberia, a new genetic study suggests.

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Stopping Ebola in its Tracks: a Community-Led Response

reliefweb.int - globalcommunities.org - December 1, 2015

The public view of the Ebola response was dominated by images and stories of medical workers and Ebola treatment units. But there is also the less-known story of the many thousands of Liberian health workers, government staff, traditional leaders and volunteers who played the most significant role in building resilience to Ebola and reducing transmission and infection. It is these groups, working in the frontlines and at significant risk, which Global Communities partnered with throughout the Ebola response.

Global Communities’ approach to countering the Ebola outbreak has been highlighted by President Obama, Dr. Rajiv Shah, former Administrator of USAID, and many others as having been a key component in the successful fight against Ebola in Liberia in the 2014-15 outbreak. This new publication “Stopping Ebola in its Tracks,” has two strands:

It describes Global Communities’ community-driven response to the Ebola outbreak in Liberia

It derives from this experience lessons learned and recommendations for preventing and dealing with future disasters

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Disease Specialists Identify Post-Ebola Threats

             

The West Africa Ebola outbreak has led experts to consider what diseases might spark the next major infectious disease crisis. Waldo Swiegers/Bloomberg via Getty Images

Scientists to assemble a rogues’ gallery of viruses likely to spark the next international public-health crisis

nature.com - by Erika Check Hayden - December 7, 2015 - doi:10.1038/nature.2015.18952

As West Africans try to bring the calamitous Ebola outbreak to an end, the World Health Organization (WHO) has called scientists and doctors to Geneva, Switzerland, on 8 and 9 December to discuss which infectious disease is likely spark the next pandemic. . . 

. . . Nature canvassed infectious-disease specialists to find out which pathogens they thought would trigger the next global crisis, and which treatments and vaccines might be readied to combat them.

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Vodafone Launches Mobile Cash Transfer System in Ghana Where 15M People Do Not Have a Bank Account

             

Moving money: The service, called M-Pesa, will be branded Vodafone Cash in the West African state

thisismoney.co.uk - by City & Finance Reporter for the Daily Mail - December 7, 2015

Vodafone has launched its mobile cash transfer system in Ghana where 15m people do not have a bank account.

The service, called M-Pesa, will be branded Vodafone Cash in the West African state. It allows mobile phone users to load money on to their phones, just as pay-as-you-go customers can top up their credit. 

They can send the funds anywhere in the country with a text message. Recipients can pick up the cash at shops that offer the service.

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Mathematical Modeling of the West Africa Ebola Epidemic

eLife 2015;10.7554/eLife.09186 - December 8, 2015
DOI: http://dx.doi.org/10.7554/eLife.09186

Abstract

As of November 2015, the Ebola virus disease (EVD) epidemic that began in West Africa in late 2013 is waning. The human toll includes more than 28,000 Ebola virus disease (EVD) cases and 11,000 deaths in Guinea, Liberia, and Sierra Leone, the most heavily-affected countries. We reviewed 66 mathematical modeling studies of the EVD epidemic published in the peer-reviewed literature to assess the key uncertainties models addressed, data used for modeling, public sharing of data and results, and model performance. Based on the review, we suggest steps to improve the use of modeling in future public health emergencies.

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Identification of NPC1 as the Target of U18666A, an Inhibitor of Lysosomal Cholesterol Export and Ebola Infection

eLife 2015;10.7554/eLife.12177 - DECEMBER 8, 2015
DOI: http://dx.doi.org/10.7554/eLife.12177

Abstract

Niemann-Pick C1 (NPC1) is a lysosomal membrane protein that exports cholesterol derived from receptor-mediated uptake of LDL, and it also mediates cellular entry of Ebola virus. Cholesterol export is inhibited by nanomolar concentrations of U18666A, a cationic sterol. To identify the target of U18666A, we synthesized U-X, a U18666A derivative with a benzophenone that permits ultraviolet-induced crosslinking. When added to CHO cells, U-X crosslinked to NPC1. Crosslinking was blocked by U18666A derivatives that block cholesterol export, but not derivatives lacking blocking activity. Crosslinking was prevented by point mutation in the sterol-sensing domain (SSD) of NPC1, but not by point mutation in the N-terminal domain (NTD). These data suggest that the SSD contains a U18666A-inhibitable site required for cholesterol export distinct from the cholesterol-binding site in the NTD. Inasmuch as inhibition of Ebola requires 100-fold higher concentrations of U18666A, the high affinity U16888A-binding site is likely not required for virus entry. 

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