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Alarm Spreads as E. Coli Cases Rise Sharply (in Europe) - With Unusual Neurological Effects

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June 1, 2011

The number of E. coli cases has risen dramatically in northern Germany, authorities announced Wednesday, with at least 180 new cases emerging in the past 24 hours in Hamburg and Lower Saxony alone.

The new figures came as doctors in Schleswig-Holstein reported that the bacterial illness was also causing unusual neurological effects including epilepsy.

Seventeen people – one in Sweden and the rest in Germany – have now died from the virulent form of enterohamorrhagic E. coli (EHEC), which can cause bloody diarrhoea and kidney failure known as haemolytic uraemic syndrome (HUS).

In the past day, the number of cases rose in Lower Saxony by 80 to 344, while in Hamburg another 99 cases were identified, bringing the total in the port city to 668.

“We are again seeing a clear rise in cases of people sick with EHEC and HUS,” Hamburg’s Health Minister Cornelia Prüfer-Storcks said. “The situation remains worrying and it is definitely too early to give any kind of all-clear.”

An 84-year-old woman who died on Sunday has now been identified as the 17th confirmed victim, the Lower Saxony Health Ministry announced Wednesday.

Authorities continued desperately to search for the source of the bacteria as Spain vented its anger over the earlier statements by Hamburg authorities that they had identified Spanish cucumbers as contaminated – a claim they have since retracted.

Spain said it was considering legal action over what it says are €200 million in losses for its farmers.

The official number of confirmed cases according to the Robert Koch Institute, the government’s public health adviser, stands at 1,064. Of these, 470 have become ill with HUS. All states are affected by three quarters of the HUS have been across northern states: Schleswig-Holstein, Hamburg, North Rhine-Westphalia and Lower Saxony.

A worrying new dimension has been reported in Schleswig-Holstein – the worst-affected state with 121 cases. Every second patient being treated for HUS at the state’s University Hospital is developing unusual neurological complications, ranging from headaches to speech problems and up to epilepsy.

“We are observing unexpected characteristics to the illness with which we’re not familiar,” said Hendrik Lehnert, director of the hospital’s Lübeck campus.

Some 91 patients are currently being treated for HUS at Lübeck and the hospital’s other campus in Kiel, 23 of them in intensive care. The neurological problems were starting about three or four days after the HUS symptoms began.

The hospital’s doctors have changed tactics and begun using antibiotics earlier than they were before, said director Stefan Schreiber.

“We have learnt something,” he said, referring to knowledge gained from an autopsy on a patient who died, which revealed that the bacteria inflamed nearly the whole stomach and intestinal tract. “The bacteria live much longer that we previously thought.”

http://www.thelocal.de/national/20110601-35405.html

http://www.bbc.co.uk/news/world-europe-13613487

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Associated Press - June 3, 2011

ATLANTA (AP) -- Four people in the U.S. were apparently sickened by the food poisoning outbreak in Europe, health officials said Friday. Three are hospitalized with a serious complication.

All four were in northern Germany in May. Though they didn't stay at the same hotel or eat at the same restaurants, officials are confident that they were infected with E. coli in that country.

Three of them - two women and a man - are hospitalized with kidney failure, a complication of E. coli that has become a hallmark of the outbreak. One of the four fell ill while on a plane to the U.S.

Two other cases are being investigated in U.S. service members in Germany, said Dr. Chris Braden, of the Centers for Disease Control and Prevention.

The source of the outbreak hasn't been pinpointed but the focus has been on fresh tomatoes, lettuce and cucumbers. More than 1,800 people have fallen ill, nearly all in Germany.

In a teleconference Friday with reporters, a Food and Drug Administration official said produce in the U.S. remains safe. The government has stepped up testing of food from Germany and Spain, but very little is imported from those countries or the rest of Europe.

The United States has "one of the safest food supplies in the world," said Don Kraemer, deputy director of the FDA's Center for Food Safety and Applied Nutrition.

Few details about the four ill people in the U.S. have been released. It's not known if they are U.S. residents or visitors. Milwaukee Health Commissioner Bevan Baker said Friday that one of the four - an adult who traveled from Germany - was in an area hospital.

Health officials have been reluctant to discuss the cases because of patient confidentiality. "We don't want there to be an overreaction, or people to feel stigmatized because they just happened to get back from Germany," said Dr. Robert Tauxe, a CDC foodborne disease expert.

The risk of the four cases triggering outbreaks in the U.S. is considered very small, he added.

"We don't think it spreads from one person to another rapidly" and will not move through the population like the flu, he said.

The CDC sent a notice to U.S. doctors Friday, advising them to be on the alert for cases.

As the investigation into the E. coli strain from the outbreak continues, CDC officials say they have never seen the strain here but are aware of at least two previous reports of a similar strain elsewhere. One was a 29-year-old woman in South Korea, reported in 2006. The other was a small cluster of cases in the Republic of Georgia in 2009.

http://hosted.ap.org/dynamic/stories/U/US_MED_CONTAMINATED_VEGETABLES_US?SITE=AP&SECTION=HOME&TEMPLATE=DEFAULT&CTIME=2011-06-03-19-04-41

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