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WHO - Ebola Situation Report - 1 April 2015

                                       

who.int - April 1, 2015

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Liberia, Sierra Leone gain in Ebola crisis; Guinea struggles

ASSOCIATED PRESS  by Sarah DiLorenzo                                                               April 2, 2015      

(Scroll below for related Wall Street Journal story.)   

DAKAR, Senegal (AP) — When will the world's largest and longest Ebola outbreak end? The West African countries of Sierra Leone and Liberia both appear to be on steady paths to ending the epidemic. The wild card is Guinea, where Ebola hasn't burned as hot but remains stubbornly entrenched.

 

In this file photo dated Friday, March. 27, 2015, a usually busy street is deserted as Sierra Leone enters a three day country wide lockdown on movement of people due to the Ebola virus in the city of Freetown, Sierra Leone. Sierra Leone's 6 million people were told to stay home for three days, except for religious services, beginning Friday as the West African nation attempted a final push to rid itself of Ebola. (AP Photo/ Michael Duff, FILE)

Liberia's last Ebola patient died March 27; it is now counting down the 42 days it must wait to be declared free of Ebola. Meanwhile, Sierra Leone recorded no new infections Wednesday for the second time; on average, it has logged a handful each day in recent days.

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Merck, NewLink Ebola vaccine appears safe, effective in new studies

REUTERS by Sharon Bagley                                                                      April 1, 2015

Early-stage trials of an experimental Ebola vaccine, two in the United States and four in Africa and Europe, have found that it appears to be safe and triggered robust production of Ebola-fighting antibodies, scientists reported on Wednesday.

Since trials cannot ethically expose volunteers to Ebola, the production of antibodies is a proxy for whether vaccines could prevent or even treat the disease.

The trials all tested a vaccine called VSV-ZEBOV, which was developed at the Public Health Agency of Canada and licensed to NewLink Genetics Corp and then to Merck & Co Inc. It consists of a cattle virus called rVSV that has been engineered to carry Ebola genes, which produce proteins meant to trigger production of anti-Ebola antibodies.

According to separate teams of scientists, that is what happened, two papers in the New England Journal of Medicine reported.

Read complete story.
http://www.reuters.com/article/2015/04/01/us-health-ebola-vaccine-idUSKBN0MS5DN20150401

Read NEW ENGLAND JOURNAL OF MEDICINE  papers

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App enables self-reporting of possible Ebola symptoms in Maryland

ASSOCIATED PRESS                                                                                     April 1, 2015

BALTIMORE — A Baltimore company and Maryland public health officials are announcing a smartphone and Web application for self-reporting possible Ebola symptoms.

Emocha Mobile Health Inc. said Wednesday that people returning from affected West African nations can use the app to report their temperature and any symptoms twice daily to the Department of Health and Mental Hygiene. The federal government recommends such reporting for 21 days.

The state health agency has operated a call center since October for monitoring people known to have been in affected countries. The app eventually will link to the state's database of such individuals to automate the reporting of data to Maryland and federal authorities.

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Ebola diaries: Regaining the people’s trust

WHO                                                                                                          March 31, 2015
Cristiana Salvi, a risk communications specialist from WHO’s European regional office was deployed to Guinea at the end of April – early May 2014 to provide social mobilization support to the Ebola response. Social mobilization involves working with communities to gain their acceptance of the need for early identification of people with illness, early treatment and identification and follow up of all people who have been in contact with people confirmed to have Ebola virus disease.

 Cristiana was among the first from WHO offices other than Headquarters and the African office to provide support to the field response, many others followed from the “wider WHO”. She travelled to Gueckedou where communities had begun to hide people who were sick, fearing treatment centres, believing rumours Ebola response teams were there for sinister purposes. This is what she found.

Excerpt:

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Faulty modeling studies led to overstated predictions of Ebola outbreak

MEDICAL EXPRESS                                                                       MARCH 31, 2015

(scroll down for complete paper.)

Frequently used approaches to understanding and forecasting emerging epidemics—including the West African Ebola outbreak—can lead to big errors that mask their own presence, according to a University of Michigan ecologist and his colleagues.

Last September, the U.S. Centers for Disease Control and Prevention estimated—based on computer modeling—that Liberia and Sierra Leone could see up to 1.4 million Ebola cases by January 2015 if the viral disease kept spreading without effective methods to contain it. Belatedly, the international community stepped up efforts to control the outbreak, and the explosive growth slowed.

"Those predictions proved to be wrong, and it was not only because of the successful intervention in West Africa," King said. "It's also because the methods people were using to make the forecasts were inappropriate."

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Guinea finds three Ebola cases in the alumina hub of Fria

REUTERS   by Saliou Samb                              March 31, 2105

CONAKRY --Guinea has detected at least three new cases of Ebola in the alumina hub of Fria, according to the national coordination of the fight against the disease, as authorities blamed popular resistance for hampering the battle against the virus.

Fria is home to the only alumina smelter in the West African country, Friguia, which produced some 630,000 tonnes of alumina a year until it was shuttered by Russian aluminium giant RUSAL in 2012.

The report noted the refusal by the local population in Conakry to hand over two other suspected cases, despite the intervention of local authorities. It said families in the town of Coyah, 50 km ( miles) from Conakry had refused to follow contacts of an Ebola case.

The resistance of local communities, which refuse to admit the existence of the disease, has dogged efforts to eradicate Ebola in Guinea since it was detected in March 2014

Read complete story.
http://www.reuters.com/article/2015/03/31/us-health-ebola-guinea-idUSKBN0MR1TL20150331

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Guinea shuts border with Sierra Leone in effort to end Ebola

ASSOCIATED PRESS by BOUBACAR DIALLO               March 30, 2015

CONKAKRY --Guinea closed its border with Sierra Leone on Monday as part of new efforts to stamp out Ebola, an official said.

... the disease remains stubbornly entrenched in Guinea more than a year after the outbreak started and authorities are now ramping up efforts to eliminate the disease.

Guinean President Alpha Conde announced this weekend that emergency measures would be "reinforced" for a 45-day period in five districts, including some along the border with Sierra Leone. The decision to close the border was made in the context of those new measures, according to Cmdr. Mamadou Alpha Barry, spokesman for the national gendarmerie.

Previously, Guinean authorities had monitored people crossing into the country for symptoms of the disease.

Read complete story.

http://www.charlotteobserver.com/living/health-family/article16925942.html

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The End of Ebola? Lessons at the Epidemic's One Year Anniversary

Columbia University                                            March 30, 2015

One year ago, the current Ebola epidemic was announced to the world. Since then, we have learned and accomplished an enormous amount....

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Ebola rapid diagnostic kit developed by UK scientists in Sierra Leone

Doctors says the kit, if approved by health authorities, could transform the admissions process with its capacity to deliver results within 20 minutes

THE GUARDIAN    by Lisa O'Carroll                              March 29, 2015

A rapid Ebola diagnostic kit similar to a pregnancy kit has been developed by British military scientists and NHS medics in Sierra Leone.

Health care workers prepare to entering a high risk zone at an Ebola virus clinic in Sierra Leone, where the diagnostic kit has been undergoing tests. Photograph: Michael Duff/AP

It can be administered at the bedside and return its first results within 20 minutes, slashing dramatically the normal 24-hour turnaround for lab results.

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