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MIT THE TECH by Jennifer F. Switzer Jan. 14, 2015
CAMBRIDGE , MA-- At the Broad Institute of MIT and Harvard, in a lab run by accomplished computational geneticist Pardis Sabeti ’97, researchers have collaborated with institutions in the U.S. and abroad to sequence and analyze more than 99 Ebola virus genomes collected by fellow scientists in Sierra Leone. They are on the lookout for mutations that could aid in developing new treatment options for Ebola, or that could serve as indications that the virus is evolving to become more deadly.
Contained within the virus’s 19,000 base-pair genome, the team has found more than 300 genetic changes that separate the 2014 Ebola virus from its predecessors. Of interest is one particular cluster of mutations which, having outlasted other genetic variations, could possibly be conferring some sort of genetic advantage to the virus ebola patients for sequencing.
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http://tech.mit.edu/V134/N62/ebola.htm
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Genomic Surveillance - Ebola Virus Origin and Transmission
sciencemag.org
Published Online August 28 2014
Science 12 September 2014:
Vol. 345 no. 6202 pp. 1369-1372
DOI: 10.1126/science.1259657
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
Abstract
In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~2000× coverage. We observed a rapid accumulation of interhost and intrahost genetic variation, allowing us to characterize patterns of viral transmission over the initial weeks of the epidemic. This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources. Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.
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