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The mission of the OneHealth Working Group is to integrate all health domains into one discipline worldwide.

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The One Health Working Group is focused on the issues of integrating all health domains into one discipline worldwide.
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Chinese Scientists Find How Bats Carry Viruses Without Getting Sick

xinhuanet.com - Editor: Liu - February 23, 2018

CLICK HERE - Dampened STING-Dependent Interferon Activation in Bats

WASHINGTON, Feb. 22 (Xinhua) -- Chinese scientists have identified the secret of bats that harbor highly pathogenic viruses like Ebola, Marburg and SARS coronavirus but do not show clinical signs of disease.

In a paper published on Thursday in the journal Cell Host & Microbe, scientists at the Wuhan Institute of Virology in China find that in bats, an antiviral immune pathway called the STING-interferon pathway is dampened, so bats can maintain just enough defense against illness without triggering a heightened immune reaction.

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BRIEF: The Virome Project Aims to Prepare Before the Next Pandemic

           

Ebola virus budding from surface of cells, from a scanning electron micrograph.  Image credits: NIAID

CLICK HERE - The Global Virome Project

insidescience.org - by Benjamin Plackett - February 22, 2018

 . . . In an article published in Science magazine today, Daszak and a group of like-minded scientists described a new initiative, called the Virome project, that would identify and catalogue hundreds of thousands of yet-to-be-discovered viruses found in wild animals.

The team estimates that there are about 1.6 million undiscovered virus types and that somewhere between 631,000-827,000 could potentially spill over into humans. The viruses are found mostly in wild mammals.

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China Confirms First Ever Human Case of H7N4 Bird Flu

           

China has confirmed first ever human case of H7N4 bird flu Photograph: Kin Cheung/AP

CLICK HERE - The Government of Hong Kong Special Administrative Region - Press Release

A 68-year-old patient from Jiangsu province, who has since recovered, developed symptoms on Christmas Day and was admitted to hospital

theguardian.com - by Tom Phillips - February 15, 2018

A woman from eastern China has been confirmed as the first ever human case of H7N4 bird flu, according to Chinese authorities . . .

 . . . The 68-year-old patient from Jiangsu province, who has since recovered, developed symptoms on 25 December, was admitted to hospital for treatment on 1 January and was released on 22 January. 

“She had contact with live poultry before the onset of symptoms,” Hong Kong’s centre for health protection (CHP) said in an alert on Wednesday evening. “According to a report from the Chinese centre for disease control and prevention, upon analysis, the genes of the virus were determined to be of avian origin.”

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The World Bank - Operational Framework for Strengthening Human, Animal and Environmental Public Health Systems at Their Interface

                                                 

documents.worldbank.org - 29 January 2018

Abstract

Public health systems have critical and clear relevance to the World Bank’s twin goals of poverty eradication and boosting shared prosperity. In particular, they are impacted by, and must respond to,significant threats at human-animal-environment interface. Most obvious are the diseases shared between humans and animals (“zoonotic” diseases), which comprise more than 60 percent of known human infectious pathogens; but also aspects of vector-borne disease, food and water safety and security, and antimicrobial resistance. Public health systems must therefore be resilient and prepared to face existing and future disease threats at the human-animal-environment interface. the Operational Framework provides a strong orientation to One Health to assist users in understanding and implementing it, from rationale to concrete guidance for its application. Six core chapters are included, supported by annexes diving deeper into operational tools and recent World Bank alignment with One Health topics, and a glossary that explains key terms, including interpretations specific to the Operational Framework.

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Bat Cave Solves Mystery of Deadly SARS Virus — and Suggests New Outbreak Could Occur

           

Researchers analysed strains of SARS virus circulating in horseshoe bats, such as this one (Rhinolophus sinicus), in a cave in Yunnan province, China.  Credit: Libiao Zhang/Guangdong Institute of Applied Biological Resource

Chinese scientists find all the genetic building blocks of SARS in a single population of horseshoe bats.

CLICK HERE - RESEARCH - Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

nature.com - by David Cyranoski - December 1, 2017

After a detective hunt across China, researchers chasing the origin of the deadly SARS virus have finally found their smoking gun. In a remote cave in Yunnan province, virologists have identified a single population of horseshoe bats that harbours virus strains with all the genetic building blocks of the one that jumped to humans in 2002, killing almost 800 people around the world. 

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Where Does the Ebola Virus Hide Between Outbreaks?

           

Photo by Steve Babuljak

ucsf.edu - by Samantha Ancona Esselmann, Samantha Hindle and Ben Mansky - October 24, 2017

Joe DeRisi, PhD, is a master detective of infectious diseases. No matter how obscure or complex, he says he’ll take on the challenge because “it could lead to new biology that we wouldn’t have discovered otherwise.”

That's precisely what happened when he stumbled on a clue to cracking the decades-long search for the place – or creature – where the Ebola virus hides between deadly outbreaks. . . .

 . . . In 2009, DeRisi began studying an incurable disease that was killing reptiles raised in captivity, a disease that caused strange neurological symptoms ranging from vomiting to uncontrollable contortions. They found the culprit – a previously undescribed arenavirus – and uncovered something surprising: the Arenavirus’s glycoprotein, a viral “access badge” to the secure insides of a cell, actually belonged to the Ebola virus.

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Is It Possible to Predict the Next Pandemic?

submitted by Carrie La Jeunesse

           

A livestock market in India - Omar Sobhani / Reuters

Large initiatives are underway to pinpoint the next big viral threats—but some virologists believe the task is too hard.

theatlantic.com - by Ed Yong - October 25, 2017

It’s been two years since an epidemic of Zika began in Brazil, three since the largest Ebola outbreak in history erupted in West Africa, eight since a pandemic of H1N1 flu swept the world, and almost a hundred since a different H1N1 flu pandemic killed 50 million people worldwide. Those viruses were all known, but no one knew when or where they’d trigger epidemics. Other diseases, like SARS, MERS, and HIV, emerged out of the blue.

Sick of being perpetually caught off guard, some scientists want to fully catalogue all viral threats, and predict which are likely to cause tomorrow’s outbreaks.

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Earth's Sixth Mass Extinction Event Under Way, Scientists Warn

Researchers talk of ‘biological annihilation’ as study reveals billions of populations of animals have been lost in recent decades

           

Earth already in midst of sixth mass extinction, scientists say

CLICK HERE - RESEARCH - PNAS - Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population losses and declines

theguardian.com - by Damian Carrington - July 10, 2017

A “biological annihilation” of wildlife in recent decades means a sixth mass extinction in Earth’s history is under way and is more severe than previously feared, according to research.

Scientists analysed both common and rare species and found billions of regional or local populations have been lost . . . 

 . . . “All signs point to ever more powerful assaults on biodiversity in the next two decades, painting a dismal picture of the future of life, including human life” . . . 

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Uptick in Creutzfeld-Jakob Cases Raises Questions

Is chronic wasting disease in deer making the jump to humans?

medpagetoday.com - by MedPage Today Staff - July 10, 2017

Cases of Creutzfeldt-Jakob disease, the fatal prion disease that's closely related to "mad cow" disease, have risen in Wisconsin and nationally in recent years, according to the Milwaukee Journal Sentinel.

In Wisconsin, there were six cases in 2002, but in two of the last four years, 13 cases have been reported -- which could be attributed to better surveillance, local officials said. Yet the increase tracks with data on chronic wasting disease among deer in the state, raising concerns about whether the illness is jumping from animals to humans.

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CLICK HERE - Milwaukee Journal Sentinel - Can chronic wasting disease jump from deer to humans? Concerns keep rising

 

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For the first time, a new strain of bird flu was transmitted human-to-human. This is highly unusual–and could be the first sign of new global pandemic.

           

Avian flu surveillance efforts. Credit: Province of British Columbia

CLICK HERE - A suspected person‑to‑person transmission of avian influenza A (H7N9)

undispatch.com - Alanna Shaikh, MPH  - May 26, 2017

 . . . a Chinese medical journal reported a human-to-human transmission of H7N9. H7N9, as mentioned, has a mortality rate of about 40%. Its impact on humans has been mitigated by the fact that it only spreads from birds. Family members can care for each other without fear.

Last week, though, China reported a case of H7N9 that appears to have spread person to person, not bird to person. The infected patient had no contact with birds or live bird markets, and he had no underlying medical condition. He was a healthy 62-year-old man, who helped a family member hospitalized with H7N9 to use the bathroom. Genetic analysis of the infecting virus indicates that he was infected with the same strain of virus that infected his family member.

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