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Why Chinese Scientists Are More Worried Than Ever About Bird Flu
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Wed, 2017-04-12 13:15 — Maeryn Obley
Image: A shop owner holds a live chicken for sale in a Hong Kong market. Isaac Lawrence /AFP/Getty Images
npr.org - April 11th 2017 - Rob Schmitz
At a research lab on top of a forested hill overlooking Hong Kong, scientists are growing viruses. They first drill tiny holes into an egg before inoculating it with avian influenza to observe how the virus behaves.
This lab at Hong Kong University is at the world's forefront of our understanding of H7N9, a deadly strain of the bird flu that has killed more people this season — 162 from September up to March 1 — than in any single season since when it was first discovered in humans four years ago.
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HK Researchers Identify Mutation in H7N9 Virus
CLICK HERE - RESEARCH - Nature Communications - An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells
news.xinhuanet.com - March 22, 2017
HONG KONG, March 22 (Xinhua) -- A mutation in H7N9 avian flu virus that can enhance the ability of the virus to infect humans was identified by researchers from the University of Hong Kong, which made the finding public on Wednesday.
The research team from the university's State Key Laboratory for Emerging Infectious Diseases of and the department of Microbiology analyzed the H7N9 virus genome collected from 2013 onwards and revealed that efficient infection of both avian and human cells by H7N9 viruses is supported by a unique nucleotide substitution (NS-G540A) in NS segment, where the mutation is located within a previously undefined exonic splicing enhancer (ESE).
Mutation in ESE identified in the viral genome of H7N9 virus enhances the ability of virus replication in mammalian cells.
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