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Zika in Fetal Brain Tissue Responds to a Popular Antibiotic

Infection of developing human brain with the Zika virus (green) highlights susceptibility of radial glial cells during fetal development. Image by Elizabeth Di Lullo

CLICK HERE - STUDY - PNAS - Zika virus cell tropism in the developing human brain and inhibition by azithromycin - by Laura Kurtzman - November 29, 2016

Working in the lab, UC San Francisco researchers have identified fetal brain tissue cells that are targeted by the Zika virus and determined that azithromycin, a common antibiotic regarded as safe for use during pregnancy, can prevent the virus from infecting these cells . . .

 . . . In the new study, published online Nov. 29, 2016, in the Proceedings of the National Academy of Sciences (PNAS), the UCSF researchers determined that the Zika virus preferentially infects brain cells with an abundance of a protein called AXL, which spans the outer cell membrane of several cell types and serves as a gateway for the invading virus . . . 

 . . . The scientists then used UCSF’s Small Molecule Discovery Center’s collection to screen 2,177 FDA-approved drugs for their ability to block Zika infection of brain cells cultured in the lab, and identified several that did, including azithromycin, a widely used antibiotic.




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