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ZMapp - Information Sheet

                                                        

ZMapp TM is the result of a collaboration between Mapp Biopharmaceutical Inc. and LeafBio (San Diego, CA), Defyrus Inc. (Toronto, Canada), the U.S. government and the Public Health Agency of Canada (PHAC).

ZMapp TM is composed of three “humanized” monoclonal antibodies manufactured in plants, specifically Nicotiana.  It is an optimized cocktail combining the best components of MB-­‐003 (Mapp) and ZMAb (Defyrus/PHAC).

ZMapp TM was first identified as a drug candidate in January 2014 and has not yet been evaluated for safety in humans.  As such very little of the drug is currently available.  

Any decision to use an experimental drug in a patient would be a decision made by the treating physician under the regulatory guidelines of the FDA.

Mapp and its partners are cooperating with appropriate government agencies to increase production as quickly as possible.

CLICK HERE - ZMapp - Information Sheet (1 page .PDF file)

http://www.mappbio.com/

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Experimental Ebola Serum Grown in Tobacco Leaves

                                                     

webmd.com - by Brenda Goodman - reviewed by Michael W. Smith, MD

Aug. 4, 2014 -- ZMapp, the experimental treatment rushed to two Americans infected with Ebola in Africa, is grown in specially modified leaves of tobacco -- a plant better known for harming health than healing.

“We complied with a request from Emory University and Samaritan’s Purse to provide a very limited amount of ZMapp last week,” says David Howard, a spokesman for Reynolds American Services, the parent company of Kentucky BioProcessing. The small biopharma company in Owensboro, KY, has been contracted to grow the drug.

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Q & A - What You Need to Know About the Ebola Outbreak

Where is the Outbreak?

      

Source: United Nations Office for the Coordination of Humanitarian Affairs

nytimes.com - by Joe Burgess, Denise Grady, Josh Keller, Heather Murphy and Sergio Peçanha - August 6, 2014

What are the chances of getting Ebola in the United States?

Two American aid workers infected with the Ebola virus while working in West Africa are being treated at a hospital in Atlanta, in a containment unit for patients with dangerous infectious diseases. But the risk that anyone will contract Ebola in the United States is extremely small, experts say.

Doctors across the country are being reminded to ask for the travel history of anybody who comes in with a fever.

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9 Questions About this New Ebola Drug

      

cnn.com - by By Jacque Wilson and Danielle Dellorto - August 5, 2014

(CNN) -- Two American missionary workers infected with the deadly Ebola virus were given an experimental drug that seems to have saved their lives.

Dr. Kent Brantly was given the medication, ZMapp, shortly after telling his doctors he thought he would die, according to a source familiar with his case. Within an hour, doctors say his symptoms -- labored breathing and a widespread rash -- dramatically improved. Nancy Writebol, another missionary working with Samaritan's Purse, received two doses of the medication and has also shown significant improvement, sources say.

As there is no proven treatment and no vaccine for Ebola, this experimental drug is raising lots of questions.

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Ebola - Information, FAQs and Research

An expanding list of information resources on Ebola Virus Disease (EVD).  A link to additional information and a timeline of related events for this outbreak will be provided (in red - here), and at the bottom of this post . . .  . . .

Office of Inspector General - Lead Inspector General Joint Strategic Oversight Plan on U.S. Government Activities: International Ebola Response and Preparedness
http://westafrica.mphise.resiliencesystem.org/lead-inspector-general-joint-strategic-oversight-plan-us-government-activities-international-ebola

Global Communities ALERT Weekly Reports
http://resiliencesystem.org/global-communities-alert-weekly-reports

US - HHS - Ebola Outbreak 2014: Information Resources
http://sis.nlm.nih.gov/dimrc/ebola_2014.html

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2nd Ebola case confirmed in Nigeria

Nigerian authorities on Monday confirmed a second case of Ebola in Africa's most populous country. The emergence of a second case raises serious concerns about the infection control practices in Nigeria, and also raise the spectre that more cases could emerge. It can take up to 21 days after exposure to the virus for symptoms to appear.

Nigerian authorities said a total of 70 people are under surveillance and that they hoped to have eight people in quarantine by the end of Monday in an isolation ward in Lagos. The emergence there is particularly worrisome because Lagos is the largest city in Africa with some 21 million people.

Nigeria is the fourth country to report Ebola cases and at least 728 other people have died in Guinea, Sierra Leone and Liberia.

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Crowdsourcing - Ebola

A growing source of information from news sources and social media on Ebola . . .

 
Voice of America – Ebola - http://www.voanews.com/info/ebola/4867.html
 
 
Crofsblogs (H5N1) – Ebola - http://crofsblogs.typepad.com/h5n1/ebola/
 
Google – (search “Ebola”) - https://www.google.com/?gws_rd=ssl#q=ebola

 

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American Doctor Sick With Ebola Now Fighting For His Life

When Dr. Kent Brantly finished his residency in Texas two years ago, he and his family immediately moved to West Africa to help people there.  JPS Health Network/AP

npr.org - by Lauren Silverman - July 29, 2014

. . . Brantly says he isn't sure how he got infected. He's certain he didn't violate any safety guidelines.

Samaritan's Purse is working with the World Health Organization and the U.S. Centers for Disease Control and Prevention to identify the source of contamination at the ward, says the group's spokesperson, Melissa Strickland.

Brantly was working with nearly two dozen Ebola patients, but Strickland says he followed strict protocols. He covered every inch of his body before entering the Ebola ward in a protective suit. "It would take at least 30 minutes to get that suit on properly," she says.

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