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The Knowledge Science working group is focused on exploring the advancement of knowledge science.

The mission of the Knowledge Science working group is to explore the advancement of knowledge science.

Members

Joyce Fedeczko Kathy Gilbeaux Maeryn Obley mdmcdonald mike kraft Siftar
tkm tom.mcginn

Email address for group

knowledge-science@m.resiliencesystem.org

How Research Data Sharing Can Save Lives

CLICK HERE - WHO - Developing Global Norms for Sharing Data and Results during Public Health Emergencies

blogs.bmj.com - by Trish Groves / The BMJ - September 8, 2015

The whole debate on sharing clinical study data has focused on transparency, reproducibility, and completing the evidence base for treatments. Yet public health emergencies such as the Ebola and MERS outbreaks provide a vitally important reason for sharing study data, usually before publication or even before submission to a journal, and ideally in a public repository.

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CLICK HERE - Wikipedia - Ingelfinger rule

 

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Scientists to share real-time genetic data on deadly MERS, Ebola

REUTERS by Kate Kelland                     April 21, 2015

LONDON, April 21 - Genetic sequence data on two of the deadliest yet most poorly understood viruses are to be made available to researchers worldwide in real time as scientists seek to speed up understanding of Ebola and MERS infections.

The project, led by British scientists with West African and Saudi Arabian collaboration, hopes to encourage laboratories around the world to use the live data -- updated as new cases emerge -- to find new ways to diagnose and treat the killer diseases, and ideally, ultimately, prevent them.

"The collective expertise of the world's infectious disease experts is more powerful than any single lab, and the best way of tapping into this...is to make data freely available as soon as possible," said Jeremy Farrar, director of the Wellcome Trust global health charity which is funding the work.

The gene sequences, already available for MERS cases and soon to come in the case of Ebola, will be posted on the website virological.org for anyone to see, access and use.

Read complete story.

http://af.reuters.com/article/topNews/idAFKBN0NC19W20150421?sp=true

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Link Removal for the Control of Stochastically Evolving Epidemics Over Networks: A Comparison of Approaches

submitted by George Hurlburt

CLICK HERE - Link Removal for the Control of Stochastically Evolving Epidemics Over Networks: A Comparison of Approaches

sciencedirect.com - Elsevier - February 16, 2015 - doi:10.1016/j.jtbi.2015.02.005

Highlights

• Disease control efforts are often constrained by limited resources.
• Limited resources can be used more effectively by leveraging network information.
• We compare four link removal algorithms to prevent disease spread under a budget.
• Optimal quarantining performs best for large budgets and structured networks.
• Knowing where an outbreak begins is most valuable at moderate budget levels.

Abstract

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Positive results spur race for Ebola vaccine

With trials under way, scientists are working out how to give vaccines in affected regions

NATURE   By Ewan Callaway                                                                                                 Dec. 2, 2014

Safety trials of Ebola vaccines are starting to return results: at least one is known to be safe and to summon an immune response against the virus.

The challenge now is to use the results to guide the larger studies that will reveal whether the vaccines work.

“The immune responses are there,” says infectious-disease researcher Adrian Hill, director of the Jenner Institute in Oxford, UK. “The tough call is whether they’re enough to protect humans against Ebola.”

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http://www.nature.com/news/positive-results-spur-race-for-ebola-vaccine-1.16468

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To halt Ebola's spread, researchers race for data

DISCOVER MAGAZINE    By Kari Lydersen                                                                              Dec. 2, 2014
.....redicting the trajectory of Ebola rather than playing catching-up could do much to help prevent and contain the disease. Some experts have called for prioritizing mobile treatment units that can be quickly relocated to the spots most needed. Figuring out where Ebola is likely to strike next or finding emerging hot spots early on would be key to the placement of these treatment centers.

But such modeling requires data, and lots of it.  And for stressed healthcare workers on the ground and government and non-profit agencies scrambling to combat a raging epidemic, collecting and disseminating data is often not a high priority.

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Bats’ Link to Ebola Finally Solved

 

THE DAILY BEAST                                                                                                           Nov. 11, 2014
By Carfrie Arnold

A new paper outlines five steps required for a virus to ‘spill over’ from bats to humans. But don’t just blame the bats—deforestation and hunting are to blame, too.

These nocturnal fliers might do some good, but their association with night, rabies, and All Things Creepy means that, at best, we tolerate them. Adding to their negative aura is recent research showing that bats can be the source of infectious diseases like SARS and Ebola, as well as lesser-known pathogens like Hendra and Nipah virus.

It’s all too easy to blame bats for causing these human pandemics, including the most recent (and deadliest) Ebola outbreak. After all, these viruses hang out in bats in between outbreaks—trace any outbreak of these viruses back far enough and you will find a bat.

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Assessing the Science of Ebola Transmission

THREE ARTICLES DESCRIBING DETAILS OF THE EBOLA VIRUS AND OTHER VIRUSES.
(Scroll Down)

Advances in microscopy have allowed scientists like Sriram Subramaniam and colleagues at the National Cancer Institute to look at the workings of tiny viruses. In this case, microscopy was used to illustrate the complex process in which human cells infected with HIV-1, green and blue, are linked to uninfected cells. Credit Illustration by Donald Bliss/N.I.H, from The Journal of Virology/American Society for Microbiology

The research on how the virus spreads is not as ambiguous as some have made it seem

THE ATLANTIC                                                                                                          Oct. 28, 2014

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Can Social Media Help Contain Ebola?

By Simon Engler - SEP 4, 2014 - 05:06 PM

Patrick Sawyer, Nigeria's first Ebola patient, collapsed at the international airport in Lagos on July 20. This Wednesday, more than six weeks later, the World Health Organization (WHO) said that it was monitoring at least 200 Nigerians for infection related to Sawyer's case. Sawyer, a Liberian-American who had traveled from Monrovia, had carried the often-fatal disease to Africa's most populous country, hundreds of miles from its origin. It was as if he had slipped through a crowd.

http://blog.foreignpolicy.com/posts/2014/09/04/the_ebola_outbreak_is_out_of_control_can_it_be_tracked_remotely

 

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Employment - World Bank - Job Description - Data Scientist

The World Bank is in search of data scientists for bigdata. Apply Now!

CLICK HERE - Job Description - Data Scientist

CLICK HERE - Job Description - Senior Data Scientist

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Eight (No, Nine!) Problems With Big Data

nytimes.com - April 6th, 2014 - Gary Marcus and Ernest Davis

Big data is suddenly everywhere. Everyone seems to be collecting it, analyzing it, making money from it and celebrating (or fearing) its powers. Whether we’re talking about analyzing zillions of Google search queries to predict flu outbreaks, or zillions of phone records to detect signs of terrorist activity, or zillions of airline stats to find the best time to buy plane tickets, big data is on the case. By combining the power of modern computing with the plentiful data of the digital era, it promises to solve virtually any problem — crime, public health, the evolution of grammar, the perils of dating — just by crunching the numbers.

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