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Africa Resilience Initiative

The mission of this working group is to articulate and shape issues of resilience and sustainability on the continent of Africa as they may be implemented as reforms of current policies, as well as contemplate and make recommendations for more extensive critiques and proposals for national, provincial, and local systems transformation, as may be necessary or desirable beyond the scope of traditional reforms being undertaken by the current African national governments and local government proposals in Africa.

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Aboubacar Conte admin Anthony bnorton Carrielaj Chisina Kapungu
ChrisAllen craig.sevcik Dr Ojia Adamolekun efrost Elhadj Drame Grace Kim
Hadiatou Balde jranck Kathy Gilbeaux mdmcdonald MDMcDonald_me_com Mike Kraft
njchapman Norea SmShako TacarraB Tjivekumba Kandjii

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Where Does the Ebola Virus Hide Between Outbreaks?

           

Photo by Steve Babuljak

ucsf.edu - by Samantha Ancona Esselmann, Samantha Hindle and Ben Mansky - October 24, 2017

Joe DeRisi, PhD, is a master detective of infectious diseases. No matter how obscure or complex, he says he’ll take on the challenge because “it could lead to new biology that we wouldn’t have discovered otherwise.”

That's precisely what happened when he stumbled on a clue to cracking the decades-long search for the place – or creature – where the Ebola virus hides between deadly outbreaks. . . .

 . . . In 2009, DeRisi began studying an incurable disease that was killing reptiles raised in captivity, a disease that caused strange neurological symptoms ranging from vomiting to uncontrollable contortions. They found the culprit – a previously undescribed arenavirus – and uncovered something surprising: the Arenavirus’s glycoprotein, a viral “access badge” to the secure insides of a cell, actually belonged to the Ebola virus.

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Polio Update: More cVDPV2 Reported in Syria, DRC

           

CLICK HERE - GPEI - THIS WEEK - Polio this week as of 9 August 2017

outbreaknewstoday.com - August 12, 2017

Additional cases of type 2 circulating vaccine-derived poliovirus (cVDPV2) have been reported recently in both Syria and the Democratic Republic of the Congo (DRC), according to the Global Polio Eradication Initiative (GPEI) this week.

Syria

Three new cases of circulating vaccine-derived poliovirus type 2 (cVDPV2) were officially confirmed at WHO headquarters in the past week, bringing the total number of cases in this outbreak to 30. Onset of paralysis of these cases is between 3 March and 16 June. Twenty-nine of the cases are from Mayadeen district, Deir Ez-Zour governorate, and one case is from Talabyad district, Raqqa governorate.

Democratic Republic of the Congo

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Ebola May Linger in Men's Semen for More Than 2 Years

Particles of Ebola virus (Zaire) obtained from cell culture fluid.  Credit: Elena Ryabchikova, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science

CLICK HERE - STUDY - Ebola Virus RNA Detection in Semen More than Two Years After Resolution of Acute Ebola Virus Infection

livescience.com - by Tia Ghose - August 1, 2017

Ebola may linger in men's semen for more than two years, a new study suggests.

What's more, at least one man who survived Ebola and then tested negative for the presence of the virus in his semen later tested positive, the new study found.

The findings raise questions about how long Ebola can linger in special immune hideouts in the body.

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Liberia - 9 Persons Die Mysteriously In Sinoe County

gnnliberia.com - by Cholo Brooks - April 25, 2017

Police in Sinoe County, southeastern Liberia, are investigation the mysterious death of nine persons after a repass of one late Edwin Dunbar, former Proprietor of One Family Entertainment Center who died few weeks ago in Greenville following a 2-night wake keeping.

According to our contact, those who died mysteriously include five females and four males, our contact said specimens from the nine deceased have been taken to Buchanan, Grand Bassa County for testing to establish the actual cause of death.

As a result of this terrible incident, officers of the Liberia National Police have been deployed in the streets of Greenville using mega phones and requesting those who ate the repass to report themselves.

Our contact said the strange and disturbing situation has created panic among citizens of the County, with others leaving for their towns and villages for fear of the unexpected.

County Health Officer John Logan when asked by our contact to speak on this prevailing situation, as to what is responsible for the mysterious deaths declined to comment on the issue.

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Huge Genome Study Dissects Ebola Outbreak's Spread

NSAID / Flickr

CLICK HERE - Nature - Virus genomes reveal factors that spread and sustained the Ebola epidemic

cidrap.umn.edu - Lisa Schnirring - April 14, 2017

The largest genome sample ever analyzed for a human epidemic reveals that the West Africa epidemic unfolded with small, overlapping outbreaks as the virus spread over short distances and that urban settings amplified the spread.

Meanwhile, another study harnessed different advanced scientific tools in the blood of a single sick patient to detail gene-level response during infection.

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CLICK HERE - Science Translational Medicine - Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease

 

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International Research Effort Reveals Major Insights Into Spread of West African Ebola Epidemic

news-medical.net - April 12, 2017

CLICK HERE - RESEARCH - Nature - Virus genomes reveal factors that spread and sustained the Ebola epidemic

An international effort to analyze the entire database of Ebola virus genomes from the 2013-2016 West African epidemic reveals insights into factors that sped or slowed the rampage and calls for using real-time sequencing and data-sharing to contain future viral disease outbreaks.

Published today in the journal Nature, the analysis found that the epidemic unfolded in small, overlapping outbreaks with surprisingly few infected travelers sparking new outbreaks elsewhere, each case representing a missed opportunity to break the transmission chain and end the epidemic sooner.

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ALSO SEE RELATED ARTICLE HERE - A big-picture look at the world’s worst Ebola epidemic

 

 

 

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UN Images: 18,000 Destroyed Structures in South Sudan Region

abcnews.go.com - by JUSTIN LYNCH, ASSOCIATED PRESS - April 7, 2017

United Nations satellite images obtained by The Associated Press show at least 18,000 structures have been destroyed in the Yei area of South Sudan. It is one of the most significant caches of evidence of widespread destruction in the country's civil war.

The Yei region has become an epicenter of fighting between government and rebels after a peace deal collapsed in July. The U.N. has highlighted the area for its risk of genocide, and an AP reporter late last year during a visit to Yei saw charred bodies with their arms bound . . .

 . . . "Where are the people? That means that 18,000 families are dead or are displaced," Ateny said.

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Cholera Spreads in Famine-threatened Somalia

           

Internally displaced Somali women gather to collect water from a plastic pan after fleeing from drought stricken regions near a makeshift camp in Baidoa, west of Somalia's capital Mogadishu, March 26, 2017.

voanews.com - March 31, 2017

BURAO, SOMALIA — Deadly cholera is spreading through drought-ravaged Somalia as clean water sources dry up, a top aid official said, deepening a humanitarian crisis in a country that is on the verge of famine.

The Horn of Africa nation has recorded more than 18,000 cases of cholera so far this year, up from around 15,000 in all of 2016 and 5,000 in a normal year, Johan Heffinck, the Somalia head of EU Humanitarian Aid, said in an email on Thursday.

The current strain of the disease is unusually deadly, killing around 1 in 45 patients.

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Blocking TLR4 Pathway May Help Control Ebola Infection

Boston University scientists curbed the host response to Ebola infection by inhibiting TLR4 in macrophages. (CDC Global CC BY 2.0)

CLICK HERE - Virology - Ebolaviruses associated with differential pathogenicity induce distinct host responses in human macrophages

fiercebiotech.com - by Amirah Al Idrus - March 23, 2017

The Ebola virus causes a disease that is often fatal, in part by infecting white blood cells called macrophages and disrupting their immune response. Boston University scientists found that using drugs that block the protein TLR4 can suppress this response and potentially control infection.

Macrophages are responsible for detecting and destroying pathogens, but the Ebola virus activates them through the Toll-like receptor 4 (TLR4) pathway, causing an inappropriate immune response. The Ebola-infected macrophages end up producing excess cytokines and chemokines—proteins that promote inflammation and worsen the disease.

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