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ZMapp - Information Sheet

                                                        

ZMapp TM is the result of a collaboration between Mapp Biopharmaceutical Inc. and LeafBio (San Diego, CA), Defyrus Inc. (Toronto, Canada), the U.S. government and the Public Health Agency of Canada (PHAC).

ZMapp TM is composed of three “humanized” monoclonal antibodies manufactured in plants, specifically Nicotiana.  It is an optimized cocktail combining the best components of MB-­‐003 (Mapp) and ZMAb (Defyrus/PHAC).

ZMapp TM was first identified as a drug candidate in January 2014 and has not yet been evaluated for safety in humans.  As such very little of the drug is currently available.  

Any decision to use an experimental drug in a patient would be a decision made by the treating physician under the regulatory guidelines of the FDA.

Mapp and its partners are cooperating with appropriate government agencies to increase production as quickly as possible.

CLICK HERE - ZMapp - Information Sheet (1 page .PDF file)

http://www.mappbio.com/

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Experimental Ebola Serum Grown in Tobacco Leaves

                                                     

webmd.com - by Brenda Goodman - reviewed by Michael W. Smith, MD

Aug. 4, 2014 -- ZMapp, the experimental treatment rushed to two Americans infected with Ebola in Africa, is grown in specially modified leaves of tobacco -- a plant better known for harming health than healing.

“We complied with a request from Emory University and Samaritan’s Purse to provide a very limited amount of ZMapp last week,” says David Howard, a spokesman for Reynolds American Services, the parent company of Kentucky BioProcessing. The small biopharma company in Owensboro, KY, has been contracted to grow the drug.

(READ COMPLETE ARTICLE)

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Q & A - What You Need to Know About the Ebola Outbreak

Where is the Outbreak?

      

Source: United Nations Office for the Coordination of Humanitarian Affairs

nytimes.com - by Joe Burgess, Denise Grady, Josh Keller, Heather Murphy and Sergio Peçanha - August 6, 2014

What are the chances of getting Ebola in the United States?

Two American aid workers infected with the Ebola virus while working in West Africa are being treated at a hospital in Atlanta, in a containment unit for patients with dangerous infectious diseases. But the risk that anyone will contract Ebola in the United States is extremely small, experts say.

Doctors across the country are being reminded to ask for the travel history of anybody who comes in with a fever.

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9 Questions About this New Ebola Drug

      

cnn.com - by By Jacque Wilson and Danielle Dellorto - August 5, 2014

(CNN) -- Two American missionary workers infected with the deadly Ebola virus were given an experimental drug that seems to have saved their lives.

Dr. Kent Brantly was given the medication, ZMapp, shortly after telling his doctors he thought he would die, according to a source familiar with his case. Within an hour, doctors say his symptoms -- labored breathing and a widespread rash -- dramatically improved. Nancy Writebol, another missionary working with Samaritan's Purse, received two doses of the medication and has also shown significant improvement, sources say.

As there is no proven treatment and no vaccine for Ebola, this experimental drug is raising lots of questions.

(READ COMPLETE ARTICLE)

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Ebola - Information, FAQs and Research

An expanding list of information resources on Ebola Virus Disease (EVD).  A link to additional information and a timeline of related events for this outbreak will be provided (in red - here), and at the bottom of this post . . .  . . .

Office of Inspector General - Lead Inspector General Joint Strategic Oversight Plan on U.S. Government Activities: International Ebola Response and Preparedness
http://westafrica.mphise.resiliencesystem.org/lead-inspector-general-joint-strategic-oversight-plan-us-government-activities-international-ebola

Global Communities ALERT Weekly Reports
http://resiliencesystem.org/global-communities-alert-weekly-reports

US - HHS - Ebola Outbreak 2014: Information Resources
http://sis.nlm.nih.gov/dimrc/ebola_2014.html

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Some Examples of Structural Adaptivity

 

As a follow-up to my post titled A New Approach, following below are several examples of how I propose that structural adaptivity should be applied as a guiding principle for future growth and development in the US.  As I explained before, I believe that structural adaptivity is the only logical approach to building our man-made environment for a rapidly changing, uncertain, unpredictable future.

 

Bus Rapid Transit.  Bus rapid transit (BRT) is a system of individual self-propelled vehicles (often several linked together) that can and do travel on conventional streets and highways, on dedicated lanes on surface streets, and/or on separate intersection-free busways dedicated to buses only.  Likewise, the rapid transit buses can leave their normal routes of travel and enter and leave most all areas of a city or region.  As a modern system providing rapid mass transit, it also normally has features similar to rail rapid transit, e.g., off-board fare collection, platform-level boarding, efficient and rapid scheduling, etc., and it oftentimes has traffic signaling priority at any street intersections.

 

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CDC - Avoid Nonessential Travel to Guinea, Liberia, and Sierra Leone

cdc.gov - July 31, 2014

CDC urges all US residents to avoid nonessential travel to Guinea, Liberia, and Sierra Leone because of an unprecedented outbreak of Ebola.

http://wwwnc.cdc.gov/travel/notices

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A New Approach

I would like to share the results of my research, thinking and writing with the U. S. Resilience System in the hopes that its viewers can incorporate some of it into their own work.  I also hope to receive feedback so I can improve my ideas.

 

My background is in city and regional planning.  More recently it has expanded to include futures research.  I believe that the much-needed resilience many of us are seeking can best be achieved if we are working on immediate plans and actions plus long-range plans and actions at the same time.  Immediate or short-term actions are seldom sufficient by themselves.

 

Resilience to the wide variety of critical problems and uncertainties we expect to face this century requires systemic changes in our country and world.  It requires changes in the way we think, act, organize and communicate, and in what and where we build.  We slowly build our man-made environment to fit our needs and then our man-made environment shapes and controls us for many decades - even after our needs have changed. 

 

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