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WHO grants ethics approval for use of experimental Ebola drug - Zmapp

The World Health Organization declared Tuesday that it's ethical to use unproven Ebola drugs and vaccines in the outbreak in West Africa provided the right conditions are met.

"In the particular circumstances of this outbreak and provided certain conditions are met, the panel reached consensus that it is ethical to offer unproven interventions with as yet unknown efficacy and adverse effects, as potential treatment or prevention," the agency said in a statement.

The panel said "more detailed analysis and discussion" are needed to decide how to achieve fair distribution in communities and among countries, since there is an extremely limited supply of the experimental drugs and vaccines.

The statement from the UN health agency came amid a worldwide debate over the medical ethics surrounding the Ebola outbreak. However the agency sidestepped the key questions of who should get the limited drugs and how that should be decided.

WHO says 1,013 people have died so far in the Ebola outbreak in West Africa and authorities have recorded 1,848 suspected or confirmed cases.

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Experimental Ebola Drug On Its Way to Liberia

      

cnn.com - by Susannah Cullinane - August 11, 2014

(CNN) -- The government of Liberia says that sample doses of the experimental Ebola drug ZMapp will be sent there to treat doctors who have contracted the deadly virus.

The White House and Food and Drug Administration approved the Liberian request for the drug to be made available to them.

Liberia identified itself as the recipient of the drug after the company that makes ZMapp said earlier that its supply was exhausted after fulfilling the request of a West African country, which it did not name.

(READ COMPLETE ARTICLE)

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Ebola Virus Info - Twitter - @InfoEbola

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Video - Ebola - A Race Against Time | MSF

http://www.msf.org.uk/ebola

https://www.youtube.com/watch?v=F5nkkEwPaEA

msf.org - July 18, 2014

146 Ebola patients have fully recovered in MSF treatment centres in Guinea & Sierra Leone.

https://twitter.com/msf_uk/status/498047294143344643

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MSF - Doctors Without Borders - Ebola Guide

 msf.org

Ebola is one of the world’s most deadly diseases. It is a highly infectious virus that can kill up to 90 percent of the people who catch it, causing terror among infected communities.

Ebola is so infectious that patients need to be treated in isolation by staff wearing protective clothing. MSF has over 670 staff on the ground and we have brought in more than 40 tonnes of equipment and supplies to help fight the epidemic.

Read MSF's response to the World Health Organisation statement declaring the Ebola outbreak "an extraordinary event".

(CLICK HERE, THEN SCROLL DOWN TO VIEW THE MSF EBOLA GUIDE)

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SOME FACILITATION EXAMPLES FOR STRUCTURAL ADAPTIVITY

  

I believe that structural adaptivity will become generally accepted in our world even without conscious effort.  As change continues speeding up, and as planners, developers, futurists, risk managers, and many others come to recognize that change is coming at an accelerating rate and that the future is ever more uncertain and unpredictable, they will focus on adaptivity.  However, the longer we wait for people to realize this, the greater the chances are that much harm will occur that should have been avoided or mitigated by the resilience we should have been already building.

 

The facilitation strategies and techniques that I propose are primarily intended to show some logical possibilities.  Hopefully other people will be better able than I am to come up with the best ones. 

 

For now, I will present the full list of the possibilities that I have come up with and then present a discussion of a few of them. <!--break-->

 

My full list:

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Nigeria's President Declares State of Emergency Over Ebola Threat

news.xinhuanet.com - August 9, 2014

ABUJA, Aug. 7 (Xinhua) -- President Goodluck Jonathan declares a national emergency in a statement on Friday, saying 1.9 billion naira (11.6 million U.S. dollars) will be released to prevent further spread of the Ebola Virus.

He also urged Nigerians to desist from spreading rumors about the virus and advised school owners across the country to consider extending the current holiday.

He directed relevant government agencies to ensure that all possible steps are taken to effectively contain the threat of the Ebola virus in line with international protocols and best practices.

(READ COMPLETE ARTICLE)

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Ebola: Official MSF Response to WHO Declaring Epidemic an "Extraordinary Event"

           

msf.org.uk - August 8, 2014

In a statement released today, the World Health Organization (WHO) declared that West Africa's Ebola epidemic is an "extraordinary event" and now constitutes an international health risk.

"A coordinated international response is deemed essential to stop and reverse the international spread of Ebola," the WHO said in a statement after a two-day meeting of its emergency committee on Ebola.

MSF reaction to WHO Ebola statement

In response, Dr Bart Janssens, Médecins Sans Frontières/Doctors Without Borders (MSF) Director of Operations said:

“Declaring Ebola an international public health emergency shows how seriously WHO is taking the current outbreak but statements won’t save lives

“Now we need this statement to translate into immediate action on the ground. For weeks, MSF has been repeating that a massive medical, epidemiological and public health response is desperately needed to saves lives and reverse the course of the epidemic.

“Lives are being lost because the response is too slow.

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ZMapp - Information Sheet

                                                        

ZMapp TM is the result of a collaboration between Mapp Biopharmaceutical Inc. and LeafBio (San Diego, CA), Defyrus Inc. (Toronto, Canada), the U.S. government and the Public Health Agency of Canada (PHAC).

ZMapp TM is composed of three “humanized” monoclonal antibodies manufactured in plants, specifically Nicotiana.  It is an optimized cocktail combining the best components of MB-­‐003 (Mapp) and ZMAb (Defyrus/PHAC).

ZMapp TM was first identified as a drug candidate in January 2014 and has not yet been evaluated for safety in humans.  As such very little of the drug is currently available.  

Any decision to use an experimental drug in a patient would be a decision made by the treating physician under the regulatory guidelines of the FDA.

Mapp and its partners are cooperating with appropriate government agencies to increase production as quickly as possible.

CLICK HERE - ZMapp - Information Sheet (1 page .PDF file)

http://www.mappbio.com/

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